Preliminary results show China’s COVID-19 vaccine candidate is safe: The Lancet

A Chinese COVID-19 vaccine candidate based on the inactivated whole SARS-CoV-2 virus is safe and elicits an antibody response. This is the result of a small, randomized, early-stage clinical trial published Thursday in the Lancet Infectious Diseases Journal.
The most recent study included participants between the ages of 18 and 80 and found that antibody responses were induced in all recipients. Participants aged 60 and over responded more slowly and took 42 days to detect antibodies in all recipients compared to 28 days for participants aged 18 to 59 years.

The study was not designed to evaluate the effectiveness of the vaccine. Therefore, it cannot be said whether the antibody responses induced by the vaccine, called BBIBP-CorV, are sufficient to protect people from SARS-CoV-2 infection.

The authors also found that the interpretation of the results of this study was limited by the short duration of follow-up.

According to The Lancet, there are currently 42 vaccines against COVID-19 in clinical trials. Vaccine candidates in clinical trials vary in nature and include DNA plasmid vaccines, inactivated virus vaccines, adenovirus vector vaccines, RNA vaccines, protein subunit vaccines, and particle virus-like vaccines. Some of these have already been shown to be safe in early clinical studies and can trigger immune responses.

“Our results show that a booster shot is necessary to achieve the best antibody responses against SARS-CoV-2 and could be important for protection. This provides useful information for a phase 3 study, ”said Yang Xiaoming, one of the authors and professor of the study at the Beijing Institute of Biological Products.

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